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Who is circling the globe this sibutramine year for The Times packs a lot of
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The most common adverse effects of liraglutide in clinical trials were nausea sometimes severe, diarrhea, vomiting, dyspepsia, and constipation. Hypoglycemia was also reported, particularly in those patients taking a sulfonylurea with liraglutide. Fewer than 10 of trial patients developed antiliraglutide antibodies, and antibody formation was not associated with decreased drug effectiveness. Pancreatitis, which has occurred with exenatide, has also been reported with liraglutide. Renal insufficiency and acute renal failure have occurred with exenatide, especially in patients who have preexisting kidney disease or are taking other drugs with a potential for nephrotoxicity. To date, renal toxicity has not been reported with liraglutide. In animal studies rats, thyroid Ccell carcinomas have developed at high liraglutide doses 8 times the clinical dose, and in human trials, thyroid Ccell hyperplasia has been reported. Thus, the FDA has required a black box warning about the risk of thyroid cancer. Liraglutide is classified as Pregnancy Category C drug and should be used with caution if nursing.




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